HRH Princess Galyani Vadhana was born on 6 May 1923 in London, England, the only daughter of HRH Prince Mahidol Adulyadej of Songkla, the sixty-ninth son of King Chulalongkorn (Rama V) and seventh son by Queen Savang Vadhana, and Miss Sangwal Talabhat. Later known as HRH Princess Srinagarindra, The Princess Mother. She was firstly named "May" on her birth certificate and was later named Mom Chao Galyani Vadhana Mahidol by King Vajiravudh (Rama VI). The word "Vadhana" in her name came from the one of her paternal grandmother, Savang Vadhana. In 1927, she was subsequently promoted to the royal rank, a Princess of Thailand (Phra Vorawongse Ther Phra Ong Chao) by King Prajadhipok (Rama VII).
In 1944, Princess Galyani Vadhana renounced her royal order of precedence in order to marry Colonel Aram Rattanakul Serireongrit between 24 August 1920 - 3 February 1982, the son of General Luang Serireongrit (Charoon Ratanakul Serireongrit), a former Army commander-in-chief around the time of World War II. They are the parents of the only daughter, Thanpuying Dasna Valaya Ratanakul Serireungriddhi but later Sorasongkram (born in 1945 in Switzerland). This marriage ended in divorce. In 1950, when the current King ascended to the throne, he reinstated her royal order of precedence.
In 1969, The Princess then married HH Prince Varananda Dhavaj (19 August 1922 - 15 September 1990), son of Prince Chudadhuj Dharadilok, Prince of Bejraburna and Mom Ravi Kayananda. They had no children.
Under the princess' royal patronage, projects included the traditional Thai arts, education, sports, social welfare, etc. She was president and honorary president of various organisations and foundations, including the Cardiac Children’s Foundation, the Princess Mother’s Charity Fund, the Autistic Foundation of Thailand. She created her own foundation for funding the studies of gifted young musicians.
She was a patron of various classical music foundations. With her trips, she always gathered important and useful information which was shown in the Royal news, giving knowledge to people. She also wrote books, poetry, and spoke French. She traveled widely within Thailand and abroad to represent the royal family and her country on missions.
The princess was admitted Siriraj Hospital in June 2007, suffering from abdominal pains. Doctors found she had cancer, and she remained in the hospital for treatment. In October 2007, doctors reported the princess had suffered an infarction on the left side of her brain as a result of occlusion of a cerebral artery.
At the same time in October, her brother, King Bhumibol Adulyadej was treated at Siriraj after he experienced weakness on his right side; doctors later found out through scans that he had a blood shortage to his brain. He was admitted on October 13 and discharged on November 7. After leaving Siriraj, the monarch has visited his sister at the hospital on an almost daily basis.
On December 14, the Royal Household Bureau released its 25th statement about the princess' health, saying she was feeling increasingly tired and was becoming less responsive.
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